Clopidogrel [Ban:Inn]

Clopidogrel [Ban:Inn] - General Information

Clopidogrel [Ban:Inn], an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to reduce atherosclerotic events such as myocardial infarction, stroke, and vascular death in patients who have had a recent stroke, recent MI, or have established peripheral vascular disease.

Pharmacology of Clopidogrel [Ban:Inn]

Clopidogrel [Ban:Inn], an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to reduce atherosclerotic events such as myocardial infarction, stroke, and vascular death in patients who have had a recent stroke, recent MI, or have established peripheral vascular disease.

Clopidogrel [Ban:Inn] for patients

Patients should be told that they may bleed more easily and it may take them longer than usual to stop bleeding when they take Plavix or Plavix combined with aspirin, and that they should report any unusual bleeding to their physician. Patients should inform physicians and dentists that they are taking Plavix and/or any other product known to affect bleeding before any surgery is scheduled and before any new drug is taken.

Clopidogrel [Ban:Inn] Interactions

Aspirin, warfarin, heparin, NSAID.

Clopidogrel [Ban:Inn] Contraindications

The use of Plavix is contraindicated in the following conditions:

· Hypersensitivity to the drug substance or any component of the product.
· Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Additional information about Clopidogrel [Ban:Inn]

Clopidogrel [Ban:Inn] Indication: For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease
Mechanism Of Action: The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel.
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Generic Name: Clopidogrel
Synonyms: Not Available
Drug Category: Antiplatelet Agents; Platelet Aggregation Inhibitors; Fibrinolytic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Clopidogrel: Clopidogrel sulfate; Clopidogrel [Ban:Inn]; Plavix;
Absorption: Absorption is at least 50% based on urinary excretion of clopidogrel-related metabolites. Bioavailability has not been found to be affected by food.
Toxicity (Overdose): Symptoms of acute toxicity include vomiting (in baboons), prostration, difficult breathing, and gastrointestinal hemorrhage.
Protein Binding: 98%
Biotransformation: Hepatic, extensive and rapid, by hydrolysis to the main circulating metabolite, a carboxylic acid derivative, which accounts for approximately 85% of the circulating drug-related compounds. A glucuronic acid derivative of the carboxylic acid derivative has also been found in plasma and urine. Neither the parent compound nor the carboxylic acid derivative has a platelet inhibiting effect.
Half Life: Carboxylic acid derivative: 8 hours (after single and multiple doses). Covalent binding to platelets has accounted for 2% of radiolabeled clopidogrel with a half-life of 11 days.
Dosage Forms of Clopidogrel [Ban:Inn]: Tablet Oral
Chemical IUPAC Name: methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
Chemical Formula: C16H16ClNO2S
Clopidogrel on Wikipedia: https://en.wikipedia.org/wiki/Clopidogrel
Organisms Affected: Humans and other mammals